People

Chin-Tu Chen, PhD

Dr. Chen's research interests, primarily in integrative multi-modality molecular imaging, cover a broad spectrum of imaging-centered topics including imaging physics and instrumentation, image reconstruction and processing, imaging tracers and probes development, physiological modeling, quantitative and intelligent image analysis, as well as applications of molecular imaging methods in a wide spectrum of biological and medical investigations, especially in cancer, brain disorders, cardiopulmonary diseases, and diabetes.

The University of Chicago
Chicago, Illinois
PhD - Medical Physics
1986

Northwester University
Evanston, Illinois
MS - Physics
1978

National Tsing-Hua University
Hsinchu, Taiwan
BS - Physics
1974

Development of a PET radioligand for potassium channels to image CNS demyelination.
Brugarolas P, Sánchez-Rodríguez JE, Tsai HM, Basuli F, Cheng SH, Zhang X, Caprariello AV, Lacroix JJ, Freifelder R, Murali D, DeJesus O, Miller RH, Swenson RE, Chen CT, Herscovitch P, Reich DS, Bezanilla F, Popko B. Development of a PET radioligand for potassium channels to image CNS demyelination. Sci Rep. 2018 01 12; 8(1):607.
PMID: 29330383

Sensitivity evaluation and selective plane imaging geometry for x-ray-induced luminescence imaging.
Quigley BP, Smith CD, Cheng SH, Souris JS, Pelizzari CA, Chen CT, Lo LW, Reft CS, Wiersma RD, La Riviere PJ. Sensitivity evaluation and selective plane imaging geometry for x-ray-induced luminescence imaging. Med Phys. 2017 Oct; 44(10):5367-5377.
PMID: 28703922

Lectin-functionalized mesoporous silica nanoparticles for endoscopic detection of premalignant colonic lesions.
Chen NT, Souris JS, Cheng SH, Chu CH, Wang YC, Konda V, Dougherty U, Bissonnette M, Mou CY, Chen CT, Lo LW. Lectin-functionalized mesoporous silica nanoparticles for endoscopic detection of premalignant colonic lesions. Nanomedicine. 2017 Aug; 13(6):1941-1952.
PMID: 28363770

Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma.
Cheng SH, Yu D, Tsai HM, Morshed RA, Kanojia D, Lo LW, Leoni L, Govind Y, Zhang L, Aboody KS, Lesniak MS, Chen CT, Balyasnikova IV. Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma. J Nucl Med. 2016 Feb; 57(2):279-84.
PMID: 26564318

Lung cancer-a fractal viewpoint.
Lennon FE, Cianci GC, Cipriani NA, Hensing TA, Zhang HJ, Chen CT, Murgu SD, Vokes EE, Vannier MW, Salgia R. Lung cancer-a fractal viewpoint. Nat Rev Clin Oncol. 2015 Nov; 12(11):664-75.
PMID: 26169924

Radioluminescence characterization of in situ x-ray nanodosimeters: Potential real-time monitors and modulators of external beam radiation therapy.
Souris JS, Cheng SH, Pelizzari C, Chen NT, La Riviere P, Chen CT, Lo LW. Radioluminescence characterization of in situ x-ray nanodosimeters: Potential real-time monitors and modulators of external beam radiation therapy. Appl Phys Lett. 2014 Nov 17; 105(20):203110.
PMID: 25425747

The vanadyl chelate bis(acetylacetonato)oxovanadium(IV) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-D-glucose by cultured human breast carcinoma cells.
Makinen MW, Bamba R, Ikejimba L, Wietholt C, Chen CT, Conzen SD. The vanadyl chelate bis(acetylacetonato)oxovanadium(IV) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-D-glucose by cultured human breast carcinoma cells. Dalton Trans. 2013 Sep 07; 42(33):11862-7.
PMID: 23644715

Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy.
Cheng Y, Morshed R, Cheng SH, Tobias A, Auffinger B, Wainwright DA, Zhang L, Yunis C, Han Y, Chen CT, Lo LW, Aboody KS, Ahmed AU, Lesniak MS. Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy. Small. 2013 Dec 20; 9(24):4123-9.
PMID: 23873826

PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension.
Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Ericson K, Zhang HJ, Han M, Haney CR, Chen CT, Sharp WW, Archer SL. PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):865-78.
PMID: 23449689

Flexible peritoneal windows for quantitative fluorescence and bioluminescence preclinical imaging.
Souris JS, Hickson JA, Msezane L, Rinker-Schaeffer CW, Chen CT. Flexible peritoneal windows for quantitative fluorescence and bioluminescence preclinical imaging. Mol Imaging. 2013 Jan-Feb; 12(1):28-38.
PMID: 23348789

View All Publications